We are investigating these questions in mouse models of depression (behavior, electrophysiology) and in human subjects (behavior, functional MRI, EEG). Classical psychedelics such as psilocybin have shown remarkable promise in ameliorating these seemingly disparate disorders, prompting a surge of interest in their mechanisms of action in both the healthy brain and in patients. Even when current treatment options are applied, these disorders often progress, reflecting the inadequacy of currently available medications for many patients. Major depressive disorder and substance use disorder are widespread and are associated with a tremendous cost in terms of family disruption, lost productivity and medical care. We study this question in a mouse model (electrophysiological recordings, protein assays), in which injection of lipopolysaccharide induces the key electrophysiological signatures of delirium (increased slow wave activity even during wakefulness, altered cortico-cortical connectivity) in order to identify the signaling pathways linking inflammation to changes in brain function. We know that inflammation is the predominant acute cause of delirium, but how inflammation induces such a drastic shift in cognition remains unclear. It is a condition that is associated with substantially increased mortality, prolonged hospital stays, and long-term cognitive deficits, but is bereft of therapeutic interventions. Delirium is an acute disorder of consciousness involving reduced attention, disorganized thinking, and fluctuating arousal levels that often affects sick elderly patients and especially those undergoing high risk surgeries.In addition, we investigate how these changes under anesthesia overlap with those observed during natural sleep in an effort to identify the neural correlates of loss and recovery of consciousness. Banks Professor, Department of Anesthesiology (608) 261-1143 Research Interests - Neural Correlates of Altered States of Consciousness Education Ph.D. We use rodent models ( in vivo and brain slice preparations patch clamp and multi-channel electrophysiological recordings calcium imaging) as well as human subjects (intracranial electrophysiological recordings from neurosurgical patients structural and functional MRI computational models) to explore the effect of anesthetic agents on signal processing (auditory, visual) and connectivity (single cell network) and relate those effects to changes in arousal. Department of Neuroscience UWMadison Matthew I. Rather, anesthetics disrupt the integrative processes of the brain through a complex set of molecular, cellular, circuit and global effects. We have shown that anesthetics do not just turn the brain off, nor are changes in information content of brain activity related simply to changes in arousal state. Despite being in widespread use since the mid-19 th century and administered to 20 million patients annually in the US alone, how anesthetics cause loss of consciousness remains one of the great open problems in biomedical science. Our areas of interest include mechanisms of loss and recovery of consciousness under anesthesia, the overlap of these mechanisms with changes in arousal during natural sleep, the link between inflammation and brain function during delirium, and the mechanisms whereby psychedelics ameliorate psychiatric disorders (depression, substance use disorder). We study this question in human subjects and rodent models using behavioral assays as well as imaging and electrophysiological measurements focused primarily in neocortex and thalamus. Research in my lab centers on how changes in brain activity and connectivity result in changes in consciousness. Commitment to Diversity, Equity, and Inclusion.Regional Anesthesia and Acute Pain Management.Chronic Pain and Pain Management Treatment.Adult Cardiothoracic and Vascular Anesthesia.Engaging faculty and students in the understanding and active practice of research which furthers their knowledge of the process of science and increases their appreciation of the balance between research and the artful practice of veterinary medicine.Creating an environment in which students and faculty interact with each other, their patients, and the community with compassion and integrity.Motivating students to pursue knowledge outside the classroom, both during their tenure at St.Helping students acquire the judgment and confidence necessary to become competent veterinarians.Providing students with the knowledge and skills needed to practice veterinary medicine in the 21st century.We are committed to achieving our mission by: Matthew's University School of Veterinary Medicine develops socially responsible veterinary doctors skilled in the art and science of veterinary medicine. Our aim is to provide qualified students from around the globe with the best veterinary training available. The core of our mission is the commitment to the success of our students.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |